Toxina botulinic\u0103 este recomandat\u0103 \u00een:<\/p>\n
- \n
- Blefarospasm<\/strong> (contrac\u021bii ale ochilor sau clipire necontrolat\u0103);<\/li>\n
- Spasme faciale<\/strong> (mi\u0219c\u0103ri involuntare ale musculaturii fe\u021bei);<\/li>\n
- Distonie focal\u0103<\/strong> (care poate fi la nivelul membrelor superioare sau inferioare);<\/li>\n
- Bruxism<\/strong> (cr\u00e2\u0219nit involuntar al din\u021bilor sau \u00eencle\u0219tare cronic\u0103 a maxilarelor);<\/li>\n
- Tremur\u0103turi<\/strong> (\u00een special ale capului \u0219i g\u00e2tului);<\/li>\n
- Ticuri<\/strong> (mi\u0219c\u0103ri involuntare ale unor anumite grupe de mu\u0219chi);<\/li>\n
- Mioclonii<\/strong> (spasm rapid involuntar la nivelul membrelor, sughi\u021bul, etc);<\/li>\n
- Spasticitatea asociat\u0103 sindromului picioarelor nelini\u0219tite<\/strong>* (tulbur\u0103ri de motricitate care deranjeaz\u0103 somnul nocturn)<\/li>\n
- Dischinezia tardiv\u0103<\/strong> (spasme faciale, grimase sau mi\u0219c\u0103ri anormale ale limbii);<\/li>\n
- Simptome asociate <\/strong>bolii Parkinson<\/strong><\/a> (\u00een special tremur\u0103turi, mi\u0219c\u0103ri necontrolabile).<\/li>\n<\/ul>\n
*folosit ca tratament doar \u00een cazuri rare.<\/p>\n
![\"\"](\"https:\/\/roneuro.ro\/blog\/wp-content\/uploads\/2025\/04\/recomandari-toxina-botulinica-scaled.jpg\" "\\"\\"")
<\/p>\nDeasemenea, este utilizat\u0103 pe scar\u0103 larg\u0103 \u0219i pentru diverse alte afec\u021biuni precum [3]:<\/p>\n
- \n
- Migrene cronice <\/strong>(cefalee de tensiune care se manifest\u0103 \u00een jurul capului, inclusiv la nivelul frun\u021bii, g\u00e2tului \u0219i \u00een spatele ochilor);<\/li>\n
- Spasme non-neurologice<\/strong> (riduri, cicatrici) o gam\u0103 larg\u0103 de probleme medicale, de la tulbur\u0103ri musculare \u0219i gastro-intestinale p\u00e2n\u0103 la afec\u021biuni urologice \u0219i dureri cronice;<\/li>\n
- Leziuni ale m\u0103duvei spin\u0103rii<\/strong> (datorate unor traumatisme, procese inflamatorii, tumori);<\/li>\n
- Spasticitate <\/strong>(scleroz\u0103 multipl\u0103<\/a>, paralizie cerebral\u0103<\/a>, traumatisme cranio-cerebrale<\/a>, scleroz\u0103 lateral\u0103 amiotrofic\u0103);<\/li>\n
- Hipersalivare<\/strong><\/li>\n
- Distonie cervical\u0103<\/strong> (contrac\u021bii involuntare ale mu\u0219chilor g\u00e2tului, care pot face ca g\u00e2tul s\u0103 se r\u0103suceasc\u0103 \u00eentr-o parte \u0219i\/sau \u00eenainte \u0219i \u00eenapoi);<\/li>\n
- Hiperhidroz\u0103 <\/strong>(transpira\u021bii excesive f\u0103r\u0103 cauze externe, precum temperatur\u0103, efort fizic);<\/li>\n
- L\u0103crimare excesiv\u0103<\/strong> (cre\u0219terea secre\u021biei glandelor lacrimare).<\/li>\n<\/ul>\n
Ce este toxina botulinic\u0103?<\/h2>\n
Toxina botulinic\u0103 este o neurotoxin\u0103 produs\u0103 de bacteria Clostridium botulinum<\/em>. Aceasta \u00eempiedic\u0103 temporar contrac\u021bia muscular\u0103 prin inhibarea eliber\u0103rii unui neurotransmi\u021b\u0103tor numit acetilcolin\u0103.<\/p>\n
\u00cen consecin\u021b\u0103, toxina botulinic\u0103 are rolul de a sl\u0103bi for\u021ba de contrac\u021bie a mu\u0219chiului tratat, pentru o anumit\u0103 perioad\u0103 de timp. Datorit\u0103 acestui mecanism, este utilizat\u0103 \u00een neurologie pentru afec\u021biuni cu contrac\u021bii musculare excesive (spasticitate, distonie etc.)[1].<\/p>\n
Ce alte aplica\u021bii clinice are toxina botulinic\u0103?<\/h2>\n
Toxina botulinic\u0103 poate fi folosit\u0103 pentru tratarea sau gestionarea altor afec\u021biuni precum:<\/p>\n
- \n
- strabism;<\/li>\n
- afec\u021biuni urologice (vezic\u0103 neurogen\u0103, vezic\u0103 hiperactiv\u0103);<\/li>\n
- boli gastro-intestinale (tulbur\u0103ri de \u00eenghi\u021bire a hranei, fisuri anale, spasticitatea sfincterului anal, etc.);<\/li>\n
- dureri cronice de spate.<\/li>\n<\/ul>\n
Aceste utiliz\u0103ri demonstreaz\u0103 versatilitatea toxinei botulinice \u00een medicin\u0103, fiind o solu\u021bie eficient\u0103 nu doar pentru estetic\u0103 sau afec\u021biuni neurologice, ci \u0219i pentru diverse alte probleme medicale.<\/p>\n
Resurse \u0219i suport pentru pacien\u021bi<\/h2>\n
Dac\u0103 ave\u021bi oricare din simptomele anterior amintite \u0219i ave\u021bi nevoie de un tratament cu toxin\u0103 botulinic\u0103, programa\u021bi-v\u0103 acum la o consulta\u021bie\u00a0<\/span>contact\u00e2nd recep\u021bia Institutului RoNeuro<\/strong> la num\u0103rul de telefon<\/span> 0374 46 2222<\/a><\/b>, luni \u0219i mar\u021bi \u00eentre orele 08:00 – 19:00<\/strong>, iar de miercuri p\u00e2n\u0103 vineri \u00eentre orele 08:00 – 18:00<\/strong>.\u00a0<\/span><\/p>\n
La momentul program\u0103rii, pute\u021bi opta \u0219i pentru consulta\u021bie neurologic\u0103 gratuit\u0103, decontat\u0103 prin Casa Na\u021bional\u0103 de Asigur\u0103ri de S\u0103n\u0103tate.\u00a0<\/span><\/p>\n
Program\u0103ri online neurologie<\/a><\/p>\n
Locui\u021bi \u00eentr-o zon\u0103 izolat\u0103 sau nu v\u0103 pute\u021bi deplasa la clinic\u0103? Institutul RoNeuro ofer\u0103 \u0219i op\u021biunea de <\/span>telemedicin\u0103<\/a>.<\/b><\/p>\n
Care sunt tipurile de toxin\u0103 botulinic\u0103 recomandate \u00een reabilitarea neurologic\u0103?<\/h2>\n
\u00cen Rom\u00e2nia, tratamentul cu toxin\u0103 botulinic\u0103 face parte din terapiile avansate \u00een reabilitarea neurologic\u0103. Exist\u0103 trei tipuri principale, fiecare cu formule u\u0219or diferite, dar acela\u0219i mecanism de ac\u021biune:<\/p>\n
- \n
- Botox <\/strong>– cea mai cunoscut\u0103 variant\u0103, utilizat\u0103 at\u00e2t \u00een medicin\u0103, c\u00e2t \u0219i \u00een estetic\u0103. Are o ac\u021biune bine studiat\u0103 \u0219i predictibil\u0103;<\/li>\n
- Dysport <\/strong>– folosit \u00een tratarea unor zone mai extinse afectate de spasticitate;<\/li>\n
- Xeomin <\/strong>– o formul\u0103 mai pur\u0103, f\u0103r\u0103 proteine complexe adi\u021bionale, ceea ce reduce riscul de a dezvolta rezisten\u021b\u0103 la tratament \u00een timp.<\/li>\n<\/ul>\n
![\"\"](\"https:\/\/roneuro.ro\/blog\/wp-content\/uploads\/2025\/04\/Tipurile-de-toxina-botulinica-scaled.jpg\" "\\"\\"")
<\/p>\n\u00cen ce const\u0103 tratamentul cu toxin\u0103 botulinic\u0103 al afec\u021biunilor neurologice?<\/h2>\n
Consulta\u021bie specializat\u0103<\/h3>\n
Pentru \u00eenceput, este necesar\u0103 o consulta\u021bie specializat\u0103, \u00een cadrul c\u0103reia se stabile\u0219te diagnosticul \u0219i se identific\u0103 zonele care necesit\u0103 tratament.\u00a0 Aceste zone sunt marcate pe piele, iar apoi se administreaz\u0103 mai multe injec\u021bii. Dozele \u0219i num\u0103rul acestora este stabilit \u00een func\u021bie de diagnosticul pacientului \u0219i severitatea afec\u021biunii. Procedura este, de obicei, bine tolerat\u0103 \u0219i provoac\u0103 un disconfort minim [4].<\/p>\n
Pacientul nu trebuie s\u0103 consume alcool \u0219i medicamente antiinflamatoare sau anticoagulante cu 24 \u00eenainte de tratament.<\/p><\/blockquote>\n
Evaluarea tipului de tratament<\/h3>\n
De exemlu, \u00een cazul distoniei focale, injec\u021biile cu toxin\u0103 botulinic\u0103 pot fi combinate \u0219i cu alte forme de tratament. \u00cen cazul blefarospasmului, injectarea se face \u00een jurul fiec\u0103rui ochi, evit\u00e2ndu-se por\u021biunea median\u0103 a pleoapelor superioare, iar cazul distoniei cervicale (numit\u0103 \u0219i torticollis), cele mai bune rezultate sunt ob\u021binute la injectarea muscular\u0103 bazat\u0103 pe electromiografie<\/a> [5].<\/p>\n
Tratamentul propriu zis<\/h3>\n
\u00cen general, \u00een tratamentul tuturor afec\u021biunilor men\u021bionate ini\u021bial, efectele toxinei botulinice depind de capacitatea sa de a bloca semnalele nervoase care ajung la mu\u0219chi, prevenind contrac\u021biile excesive. Acest mecanism de ac\u021biune o face eficient\u0103 \u00een tratamentul afec\u021biunilor caracterizate de spasme musculare sau mi\u0219c\u0103ri involuntare<\/em> [6].<\/p>\n
Dup\u0103 tratament pacientul prime\u0219te c\u00e2teva sfaturi de \u00eengrijire ulterioar\u0103, precum evitarea efortului fizic timp de o zi sau dou\u0103, evitarea atingerii zonelor injectate \u0219i men\u021binerea capului ridicat (dac\u0103 e cazul) timp de c\u00e2teva ore.<\/p>\n
Dup\u0103 c\u00e2t timp apar rezultatele\u00a0tratamentului cu toxin\u0103 botulinic\u0103?<\/h2>\n
Rezultatele injec\u021biilor cu toxin\u0103 botulinic\u0103 nu sunt imediate, dar pot fi observate unele \u00eembun\u0103t\u0103\u021biri dup\u0103 c\u00e2teva zile iar efecte evidente dup\u0103 aproximativ dou\u0103 s\u0103pt\u0103m\u00e2ni. Mu\u0219chii trata\u021bi se relaxeaz\u0103, iar efectele tratamentului dureaz\u0103 \u00eentre trei \u0219i \u0219ase luni. Mai apoi tratamentul se poate relua dac\u0103 e cazul [7].<\/p>\n
Care sunt efectele secundare ale tratamentului cu toxin\u0103 botulinic\u0103?<\/h2>\n
Folosit\u0103 \u00een doze terapeutice, toxina botulinic\u0103 care are pu\u021bine efecte secundare precum sl\u0103biciune muscular\u0103, oboseal\u0103, simptome asem\u0103n\u0103toare gripei, gur\u0103 uscat\u0103, ame\u021beli \u0219i erup\u021bii cutanate [8].<\/p>\n
Cu toate acestea, prescrierea tratamentului trebuie s\u0103 aibe \u00een vedere factorii care ar putea predispune la apari\u021bia unor efecte adverse mai severe \u0219i adoptarea unor strategii de prevenire sau tratare a acestora [9]. Injectiile nu sunt recomandate \u00een timpul sarcinii, dec\u00e2t \u00een situa\u021bii excep\u021bionale, la indicarea medicului, deoarece au poten\u021bial nociv.<\/p>\n
Concluzii<\/h2>\n
Toxina botulinic\u0103 face parte din tratamentele esen\u021biale ale celor mai multe tulbur\u0103ri neurologice, dar este utilizat\u0103 \u0219i pentru tratamentul unor afec\u021biuni non-neurologice sau cu scop estetic.<\/p>\n
\u021ainta terapeutic\u0103 a tratamentului cu toxin\u0103 botulinic\u0103 const\u0103 \u00een \u00eembun\u0103t\u0103\u021birea func\u021bionalit\u0103\u021bii pacientului \u0219i cre\u0219terea calit\u0103\u021bii vie\u021bii. Dac\u0103 simptomele revin, tratamentul se poate relua, dar nu mai devreme de trei luni.<\/p>\n
Este important ca planul de tratament s\u0103 \u00eenceap\u0103 c\u00e2t mai cur\u00e2nd posibil, deoarece promptitudinea interven\u021biei neurologice poate avea un impact semnificativ asupra rezultatelor pe termen lung.<\/p>\n
Referin\u021be<\/h2>\n
- \n
- Yeditepe University Hospital, The Use of Botox in Neurological Diseases. Available at: https:\/\/yeditepehastaneleri.com\/en\/health-guide\/diseases-treatments\/use-botox-neurological-diseases<\/a><\/li>\n
- Anandan C, Jankovic J. Botulinum Toxin in Movement Disorders: An Update. Toxins (Basel). 2021 Jan 8;13(1):42. doi: 10.3390\/toxins13010042. Available at: https:\/\/pubmed.ncbi.nlm.nih.gov\/33430071\/<\/a><\/li>\n
- Dorneanu I , Bunzol D. Rush University Medical Center, 5 Neurological Conditions You Can Treat With Botox. Available at: https:\/\/www.rush.edu\/news\/5-neurological-conditions-you-can-treat-botox<\/a><\/li>\n
- Mayo Foundation for Medical Education and Research, Botox injections. Available at: https:\/\/www.mayoclinic.org\/tests-procedures\/botox\/about\/pac-20384658<\/a><\/li>\n
- Comella CL, Buchman AS, Tanner CM, Brown-Toms NC, Goetz CG. Botulinum toxin injection for spasmodic torticollis: Increased magnitude of benefit with electromyographic assistance. Neurology. 1992;42:878\u201382. doi: 10.1212\/wnl.42.4.878. Available at: https:\/\/pubmed.ncbi.nlm.nih.gov\/1565246\/<\/a><\/li>\n
- Simpson LL. Identification of the major steps in botulinum toxin action. Annu Rev Pharmacol Toxicol. 2004;44:167-93. doi: 10.1146\/annurev.pharmtox.44.101802.121554. PMID: 14744243. https:\/\/pubmed.ncbi.nlm.nih.gov\/14744243\/<\/a><\/li>\n
- Jabeen A, Kandadai RM, Kannikannan MA, Borgohain R. Guidelines for the use of botulinum toxin in movement disorders and spasticity. Ann Indian Acad Neurol. 2011 Jul;14(Suppl 1):S31-4. doi: 10.4103\/0972-2327.83099. Available at: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3152173\/<\/a><\/li>\n
- Bakheit AM. The possible adverse effects of intramuscular botulinum toxin injections and their management. Curr Drug Saf. 2006 Aug;1(3):271-9. doi: 10.2174\/157488606777934431. Available at: https:\/\/pubmed.ncbi.nlm.nih.gov\/18690938\/<\/a><\/li>\n
- Varghese-Kroll E, Elovic EP. Contralateral weakness and fatigue after high-dose botulinum toxin injection for management of poststroke spasticity. Am J Phys Med Rehabil. 2009 Jun;88(6):495-9. doi: 10.1097\/PHM.0b013e3181a5b056. Available at: https:\/\/pubmed.ncbi.nlm.nih.gov\/19454855\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
Afec\u021biuni neurologice tratate cu toxina botulinic\u0103 Toxina botulinic\u0103 este utilizat\u0103 de peste 35 de ani \u00een tratamentul diverselor afec\u021biuni neurologice \u0219i non-neurologice [2]. Administrat\u0103 prin injectare, toxina botulinic\u0103 creeaz\u0103 o imobilizare par\u021bial\u0103 temporar\u0103 a mu\u0219chilor dar numai la locul inocul\u0103rii, \u00een restul zonelor va apare doar o compensare contractil\u0103 a mu\u0219chilor. Din acest motiv, toxina […]<\/p>\n","protected":false},"author":2,"featured_media":1724,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":{"format":"standard","override":[{"template":"6","parallax":"1","fullscreen":"1","layout":"no-sidebar","sidebar":"default-sidebar","second_sidebar":"default-sidebar","sticky_sidebar":"1","share_position":"floatbottom","share_float_style":"share-normal","show_share_counter":"1","show_view_counter":"1","show_featured":"1","show_post_meta":"1","show_post_author_image":"1","show_post_date":"1","post_date_format":"default","post_date_format_custom":"Y\/m\/d","show_post_category":"1","show_post_reading_time":"1","post_reading_time_wpm":"300","post_calculate_word_method":"str_word_count","show_zoom_button":"1","zoom_button_out_step":"2","zoom_button_in_step":"3","show_post_tag":"1","show_popup_post":"1","number_popup_post":"3","show_post_related":"1","show_inline_post_related":"0"}],"image_override":[{"single_post_thumbnail_size":"crop-500","single_post_gallery_size":"crop-500"}],"trending_post_position":"meta","trending_post_label":"Trending","sponsored_post_label":"Sponsored by","disable_ad":"0","subtitle":""},"jnews_primary_category":[],"jnews_override_counter":{"view_counter_number":"0","share_counter_number":"0","like_counter_number":"0","dislike_counter_number":"0"},"footnotes":""},"categories":[6],"tags":[],"class_list":["post-1716","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neurologie"],"_links":{"self":[{"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/posts\/1716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/comments?post=1716"}],"version-history":[{"count":2,"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/posts\/1716\/revisions"}],"predecessor-version":[{"id":1723,"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/posts\/1716\/revisions\/1723"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/media\/1724"}],"wp:attachment":[{"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/media?parent=1716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/categories?post=1716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/roneuro.ro\/blog\/wp-json\/wp\/v2\/tags?post=1716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- Anandan C, Jankovic J. Botulinum Toxin in Movement Disorders: An Update. Toxins (Basel). 2021 Jan 8;13(1):42. doi: 10.3390\/toxins13010042. Available at: https:\/\/pubmed.ncbi.nlm.nih.gov\/33430071\/<\/a><\/li>\n
- Dysport <\/strong>– folosit \u00een tratarea unor zone mai extinse afectate de spasticitate;<\/li>\n
- Botox <\/strong>– cea mai cunoscut\u0103 variant\u0103, utilizat\u0103 at\u00e2t \u00een medicin\u0103, c\u00e2t \u0219i \u00een estetic\u0103. Are o ac\u021biune bine studiat\u0103 \u0219i predictibil\u0103;<\/li>\n
- Spasme non-neurologice<\/strong> (riduri, cicatrici) o gam\u0103 larg\u0103 de probleme medicale, de la tulbur\u0103ri musculare \u0219i gastro-intestinale p\u00e2n\u0103 la afec\u021biuni urologice \u0219i dureri cronice;<\/li>\n
- Spasme faciale<\/strong> (mi\u0219c\u0103ri involuntare ale musculaturii fe\u021bei);<\/li>\n